CN
Metabolic Diseases

NASH and NAFLD

WuXi AppTec has developed and validated animal models of NASH that captures key features seen in man. Mice are first fed with high-fat diet (HFD) to induced obesity. Carbon tetrachloride is then used to induce liver damages, leading to inflammation, cell death and fibrosis.  

WuXi’s HFD-CCL4 NASH Model

 
  • Fibrosis validation
  • Histopathology validation
  • Biomarkers validation
  • In vivo efficacy test for NASH and related animals models
  • Animal study design
 

Diabetes; Obesity, Dyslipidemia