WuXi AppTec has developed and validated animal models of NASH that captures key features seen in man. Mice are first fed with high-fat diet (HFD) to induced obesity. Carbon tetrachloride is then used to induce liver damages, leading to inflammation, cell death and fibrosis.
WuXi’s HFD-CCL4 NASH Model
In vivo efficacy test for NASH and related animals models