CN
Immuno-oncology

Outstanding Platform to Enable Cancer Immunotherapy with One Stop Service

  • Immunological function assessment
  • Tumor microenvironment analysis
  • In vivo efficacy evaluation on animal models
  • NGS to understand TCR/BCR Repertoire
  • Patient TILs analysis
 

Immuno-oncology In Vitro Functional Assays

  • Immune cell activation assays
  •      - T/B/NK cell activation
  • Macrophage differentiation assays
  •      - M1/M2 macrophage differentiation
  •      - DC differentiation
  •      - MDSC induction
  • T cell polarization assays
  •      - Treg/Th1/Th2/Th17 differentiation
  • T cell cytotoxicity assay
  •      - Cytotoxic T lymphocyte assay (OT-1 system)
  • Mixed Lymphocyte Reaction
  • Immune cell suppressive assay
  •      - MDSC/Treg/Tumor-T suppressive assay
  • Antibody mediated immunological assay
  •      - ADCC/CDC/ADCP
   

Immuno-oncology In Vitro Technical Competence   

Immune cell profiling in tumor infiltrating leukocyte (TIL) and other tissues (spleen, blood, lymph node, liver, etc.) profiling: (1) Immune cell population analysis (T, B, NK, DC, Myeloid, Macrophage, Granulocyte, CD4+T, CD8+T, Treg, Th1/2/17, naïve/memory/effector T, g/mMDSC, M1/M2, etc.) (2) Functional and intracellular marker analysis (PD-1, PD-L1/2, CTLA-4, TIM-3, LAG-3, OX40, 4-1BB, ICOS, Ki-67, IL-2, IL-17, IFNγ, TNFα, Granzyme B, etc.)  

Biomarker

  • Soluble biomarker – ELISA, ELISPOT
  • Cell-based biomarker – FACS
  • Tissue-based biomarker – Multiplex IHC
  • Gene expression profiling-RNAseq, Nanostring
 

Tumor Infiltrating Lymphocytes (TILs) Analysis on Human and Murine Tumor Tissues

  • CD4, CD8, MDSC, M1/M2, DC cell, NK cell, B cell
  • PD1, TIM3, LAG3, OX40, 4-1BB
  • Treg, Th1,2,3,17 …
 

In Vivo Efficacy Evaluation on Animal Models Syngeneic Murine Models

  • Immune-checkpoint humanized models
  • Immune-Avatar humanized models PBMC humanized models
  • HSC humanized models
 

TM (Tumor Microenvironment) Analysis for Immunoscore by FACS, IHC and IF

  • CTLs, NK, Tregs, MDSC, TAM, etc.
 

Lymphoid Tissue and Peripheral Blood Analysis

  • Immune cell populations and subsets – frequency, activation, and differentiation
  • Cytokine and chemokine analysis
  • Anatomical localization ofin vivo anti-tumor immune responses
 

Adoptive T Cell Therapy