Inflammatory bowel disease (IBD) is an autoimmune disease caused by a dysregulated immune response to host intestinal microbiota. There are two major types of IBD: ulcerative colitis (UC) and Crohn’s disease (CD). Irritable bowel syndrome (IBS) is a condition that produces similar symptoms to those of IBD but without GI tract inflammation. More than 5 million population live with a form of IBD and 0.7 billion people suffer with IBS. Currently there is no well-developed cure for IBD or IBS. As part of WuXi Research Service Division (RSD), the Biology Unit, led by a group of leading scientists with significant experience in drug discovery, has fully developed IBD/IBS animal models for new compound development for both IBD and IBS.
WuXi AppTec IBD/IBS Models
The following models of IBD/IBS are available at WuXi:
DSS-Induced IBD: Acute
DSS-Induced IBD: Chronic
T Cell Transfer Model of Colitis
Telemetry Irritable bowel syndrome (IBS) model
Time course of body weight change
Disease scores, organ length and weight
Blood biochemical analysis, including white cells and interleukins etc.
Histopathology scoring of collected tissue
Telemetry EMG signaling and analysis for IBS
A Custom Protocol is designed for a study to meet Sponsor’s requirements.Figure 1. Cyclosporin A effects in IBD modelFigure 2. Tegaserod effects on EMG in IBS model