G-protein coupled receptors (GPCRs) forms the largest class of cell-surface receptors. There are ~ 800 GPCRs overall, and as such this target clas is very important in drug discovery. Currently around, ~ 35% of all drugs approved by the FDA act at 108 unique GPCRs1.
1. Hauser et al. (2017). Trends in GPCR drug discovery: New agents, targets and indications Nature Reviews Drug Discovery 16(12): 829–842
Comprehensive In Vitro GPCR Services
R&D programs: MOA
MTS and HTS
Assay transfer, setup and/or development
Stable GPCR cell line generation
Over 100 GPCR cell lines and corresponding assays in house (Read More)
GPCR assays for safety/off-target profiling (Read More)
Customized assays are routinely provided by scientific teams upon request.
Transporter and NHR (Nuclear Hormone Receptor) Assays
Radioligand binding and functional assays (Read More for Targets and Assays)