WuXi offers fast and cost-efficient hit identification by fragment screening or virtual high-throughput screening. We have several well-tended fragment libraries totaling more than 5,000 compounds. In addition, client libraries can easily be integrated in our workflow. With a virtual library comprises of over six million compounds our computational iterative scoring and learning cycle quickly extracts 300+ top scoring molecules, which can subsequently undergo hit confirmation. From here a suite of orthogonal hit confirmation assays, including SPR, MST, DSF/nanoDSF, NMR or MS based methods, allowing for the selection of the best biophysical test system for each target. Subsequent fragment hits can be validated with an orthogonal method and subjected to crystallization.