CN
Autoimmune and inflammatory animal models

Autoimmune and Inflammation Models 

1) Autoimmune arthritis
  • Collagen induced arthritis (CIA) in DBA/1 mice
  • Adjuvant induced arthritis (AIA) in Lewis rats
  • hTNFα transgenic mice - a spontaneous model
2) Experimental autoimmune encephalomyelitis 3) Delayed type hypersensitivity (DTH)
  • Oxazolone-induced DTH in mice
  • DNFB-induced DTH in mice
4) Psoriasis-Imiquimod-induced psoriasis-like skin inflammation  5) IBD-Naive T cell transfer induced Colitis 6) Systemic lupus erythematosusSLEin MRL mice  

Rheumatoid Arthritis (RA) Models     

  • Collagen-induced arthritis (CIA) in DBA/1 mice
  • Collagen-induced arthritis (CIA) in Lewis rats
  • Adjuvant-induced arthritis (AIA) in Lewis rats
  • hTNFa transgenic mice
 

Multiple Sclerosis (MS) Models

  • MOG-induced (experimental autoimmune encephalomyelitis, EAE) in C57BL/6 mice
  • MBP-induced EAE in Lewis rats
  • PLP-induced relapsing-remitting EAE in SJL mice
 

Delayed Type Hypersensitivity (DTH) Models              

  • Oxazolone-induced DTH in mice
  • DNFB-induced DTH in mice
 

Psoriasis Model

  • Imiquimod-induced psoriasis-like skin inflammation in mice
  • IL-23-induced eczema in mice
 

Inflammatory Bowel Disease (IBD) Model

  • DSS-induced colitis in C57BL/6 mice
  • TNBS-induced colitis in mice
 

Gout Models

  • Oteracil potassium-induced hyperuricemia
  • MSU-induced air pouch inflammation
 

Acute Inflammation In Vivo

  • LPS-induced airway inflammation in Wistar rats
  • LPS-induced cytokine model in mice and rats
  • ConA-induced cytokine model in mice and rats
  • R848 (Resiquimod) induced cytokine model in mice and rats
 

In Vitro Assays

  • Cell based in vitro screening (PBMC)
  • Cell based in vitro screening (Cell line and Multiplex)